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RS BioTherapeutics Selects Recipharm as Product Characterization Partner

Takes important step towards filing an IND for RSBT-001 in the treatment of COPD

November 14, 2022 10:00 ET | Source: RS BioTherapeutics

CUMBERLAND, Md., Nov. 14, 2022 (GLOBE NEWSWIRE) — RS BioTherapeutics, whose mission is to harness its strong and thorough understanding of the endocannabinoid system (ECS) to research, develop and commercialize interventions to address chronic and acute pulmonary (lung) inflammation-based diseases, is pleased to announce that is has selected Recipharm, a leading Contract Development and Manufacturing Organization (CDMO), as its partner to conduct product characterization for its investigational compound, RSBT-001.

 

Product characterization is an important next step for RSBT-001 before filing an Investigational New Drug (IND) application with the FDA for the treatment of chronic obstructive pulmonary disease (COPD).

 

Commenting on the partnership, Justin Molignoni, Chief Strategy Officer of RS BioTherapeutics said, “We are very pleased to partner with Recipharm for product characterization testing to support the development of RSBT-001 as a treatment for COPD. Recipharm is one of the world’s leading pharmaceutical Contract Development and Manufacturing Organizations (CDMOs) that is actively involved in the development of therapeutics for pulmonary and systemic diseases. We are excited to leverage their experience and expertise.”

 

Chris Hirst, Head of Recipharm’s Advanced Delivery Systems Business Unit said, “Recipharm is delighted to be working with RS BioTherapeutics, providing product characterization testing to support the development of RSBT-001. We look forward to being able to support RS BioTherapeutics’ understanding of the endocannabinoid system as it drives to commercialize new therapies for chronic and acute pulmonary inflammation-based diseases.”

In July, RS BioTherapeutics announced positive results from its proof-of-concept study with its development partner Synthonics and Marshall University, for RSBT-001. RSBT-001 is a patent-pending, nebulized, semi-synthetic, cannabidiolic acid complex in development to address exacerbation and prevent progression of both acute and chronic pulmonary inflammation related to respiratory diseases including COPD, SARS-COV-2, Cystic Fibrosis, Asthma, Bronchitis, and Acute Respiratory Distress Syndrome.

 

About RS BioTherapeutics
Founded by experts in pulmonary diseases and the endocannabinoid system, RS BioTherapeutics is a wholly owned subsidiary of Real Science Holdco LLC. The company’s mission is to harness its strong and thorough understanding of the Endocannabinoid System in the research, development, and commercialization of forward-thinking interventions to address chronic and acute pulmonary inflammation-based diseases. More information on RS BioTherapeutics can be found at www.rsbiotherapeutics.com.

 

About Recipharm
Recipharm is a leading Contract Development and Manufacturing Organization (CDMO) in the pharmaceutical industry employing almost 9,000 employees. Recipharm offers manufacturing services of pharmaceuticals in various dosage forms, production of clinical trial material and APIs, pharmaceutical product development and development and manufacturing of medical devices. Recipharm manufactures several hundred different products to customers ranging from big pharma to smaller research and development companies. The company operates development and manufacturing facilities in France, Germany, India, Israel, Italy, Portugal, Spain, Sweden, the UK and the US and is headquartered in Stockholm, Sweden.

 

For more information on Recipharm and its services, please visit www.recipharm.com.

 

Media Contacts: David Gutierrez, Dresner Corporate Services for RS BioTherapeutics, (312) 780-7204, dgutierrez@dresnerco.com

 

View Original Publication | Global News Wire

RS BioTherapeutics Secures $3 Million Seed II Round of Funding

September 26, 2022 09:34 ET | Source: RS BioTherapeutics

CUMBERLAND, Md., Sept. 26, 2022 (GLOBE NEWSWIRE) — RS BioTherapeutics, whose mission is to harness its strong and thorough understanding of the endocannabinoid system (ECS) to research, develop and commercialize interventions to address chronic and acute pulmonary (lung) inflammation-based diseases, is pleased to announce that is has secured a $3 million Seed II round of funding.

 

In July, RS BioTherapeutics announced positive results from its proof-of-concept study with its development partner Synthonics and Marshall University, for its first investigational compound, RSBT-001. RSBT-001 is a patent-pending, nebulized, semi-synthetic, cannabidiolic acid complex in development to address exacerbation and prevent progression of both acute and chronic pulmonary inflammation related to respiratory diseases including COPD, SARS-COV-2, Cystic Fibrosis, Asthma, Bronchitis, and Acute Respiratory Distress Syndrome.

 

In August, the company announced that it is planning a biotherapeutics cultivation and manufacturing site in the Cumberland, Maryland area, which could potentially generate 100 high paying jobs within the next five years.

 

Commenting on the raise, Justin Molignoni, Chief Strategy Officer of RS BioTherapeutics said, “Closing this round of funding is an exciting milestone which will help accelerate the growth of the company. These funds will not only support our growing organization but also our development of RSBT-001 as we work towards an IND submission.”

 

About RS BioTherapeutics

Founded by experts in pulmonary diseases and the endocannabinoid system, RS BioTherapeutics is a wholly owned subsidiary of Real Science Holdco LLC. The company’s mission is to harness its strong and thorough understanding of the Endocannabinoid System in the research, development, and commercialization of forward-thinking interventions to address chronic and acute pulmonary inflammation-based diseases. More information on RS Biotherapeutics can be found at www.rsbiotherapeutics.com.

 

View Original Publication | Global News Wire

RS Biotherapeutics Appoints Jeremy Plumb as Chief Cultivation Officer

Supports the company’s plans to build a biotherapeutics cultivation and manufacturing site in Cumberland, Maryland

August 01, 2022 10:00 ET | Source: RS BioTherapeutics

CUMBERLAND, Md., Aug. 01, 2022 (GLOBE NEWSWIRE) — RS BioTherapeutics, whose mission is to harness its strong and thorough understanding of the endocannabinoid system (ECS) to research, develop and commercialize interventions to address chronic and acute pulmonary (lung) inflammation-based diseases, is pleased to announce that it has appointed Jeremy Plumb as its Chief Cultivation Officer. Mr. Plumb will play an integral role in the company’s plans to develop a biotherapeutics cultivation and manufacturing site in the Cumberland, Maryland area, which could potentially generate 100 high paying jobs within the next five years.

 

Prior to joining RS BioTherapeutics, Mr. Plumb served as the Director of Production Science at Groundworks Industries, one of the largest Oregon-owned and operated cannabis companies, as well as its portfolio brand, Prūf Cultivar, which operates one of the most technologically advanced controlled environment agriculture (CEA) cultivation facilities in North America. At Prūf, Jeremy combined his decades of cannabis horticulture experience with cutting-edge technology to deliver previously unattainable consistency in product quality.

 

Mr. Plumb has also served as a cannabis consultant to Israel medical cannabis researchers and as a cannabis policy advisor for members of the U.S. Congress. He also serves on the Oregon Liquor Control Commission’s rule-making advisory committee, is a founding member of Smart Cannabis, and serves on the technical advisory committee of the Resource Innovation Institute. In addition, he is a board member of the MCRC (Multidimensional Cannabis Research Center) based at Kathmandu University and serves as an advisory board member of Node Labs, a botanical tissue culture company based in San Francisco, California. Mr. Plumb holds a Bachelor of Arts in Ecology from the New College of California and a Master of Arts in Psychology from the Pacific Graduate Institute.

 

Commenting on the appointment, Justin Molignoni, Chief Strategy Officer of RS BioTherapeutics said, “We are honored to welcome Jeremy Plumb to our talented leadership team. Jeremy is one of the most well-respected CEA cultivators in the world and will play a vital role in helping RS BioTherapeutics establish and scale our cultivation and manufacturing operation to support the development of our first investigational compound, RSBT-001 as well as other endocannabinoid system-focused therapeutics.”

 

Jeremy Plumb said, “I am very excited to join the RS BioTherapeutics team and support the research, development, and commercialization of forward-thinking endocannabinoid system-focused interventions to address chronic and acute pulmonary inflammation-based diseases. I have long advocated for therapies focused upon the endocannabinoid system and have dedicated my work to understanding phenotypic plasticity and what it takes to support the most useful therapeutic profiles.”

 

About RS BioTherapeutics

Founded by experts in pulmonary diseases and the endocannabinoid system, RS BioTherapeutics is a wholly owned subsidiary of Real Science Holdco LLC. The company’s mission is to harness its strong and thorough understanding of the Endocannabinoid System in the research, development, and commercialization of forward-thinking interventions to address chronic and acute pulmonary inflammation-based diseases. More information on RS Biotherapeutics can be found at www.rsbiotherapeutics.com.

 

View original publication | Global News Wire

RS Biotherapeutics Reports Positive Results From Proof-of-Concept Trial for First Investigational Compound

Data supports theory that RSBT-001 can positively impact damaging inflammation without eliminating beneficial immune response

July 11, 2022 11:00 ET | Source: RS BioTherapeutics

CUMBERLAND, Md., July 11, 2022 (GLOBE NEWSWIRE) — RS BioTherapeutics, whose mission is to harness its strong and thorough understanding of the endocannabinoid system (ECS) to research, develop and commercialize interventions to address chronic and acute pulmonary (lung) inflammation-based diseases, is pleased to announce positive results from its proof-of-concept study for its first investigational compound, RSBT-001.

RSBT-001 is a patent-pending, nebulized, semi-synthetic, cannabidiolic acid (CBDa) complex in development to address exacerbation and prevent progression of both acute and chronic pulmonary inflammation related to respiratory diseases including COPD, SARS-COV-2, Cystic Fibrosis, Asthma, Bronchitis, and Acute Respiratory Distress Syndrome.

 

RS BioTherapeutics conducted the study in conjunction with RSBT-001 development partner, Synthonics, Inc., and Marshall University using a mouse model of pulmonary inflammation.

 

The proof of concept model was created by instilling E. coli derived lipopolysaccharide (LPS) intranasally. Anti-inflammatory response was determined by measuring a series of cytokines known to be highly expressed in response to pulmonary inflammation. RSBT-001 was dosed at 1 mg/kg intranasally and its performance was measured against a positive control, dexamethasone, at 2.5 mg/kg and 10.0 mg/kg dosed intranasally; a negative control (LPS only); and vehicle only. Both RSBT-001 and dexamethasone were administered in a single dose 8 hours after insult. Cytokine measurements were made with mouse lung homogenate at 12 hours, 24 hours, and 48 hours after test material administration.

 

Justin Molignoni, CRNP, Chief Strategy Officer and Co-Chair of the RS BioTherapeutics Joint Development Committee said, “The data from the proof-of-concept trial clearly indicates that RSBT-001 reduces cytokine level, and that this cytokine reduction is appropriately transient. This supports the theory that RSBT-001 can reduce the harmful effects of an overstimulated immune system, which causes damaging inflammation, but does not completely suppress the immune response, which is important to retain in order to continue to fight off the insult or infection.”

 

Thomas Piccariello, Ph.D., Co-Chair of the RS BioTherapeutics Joint Development Committee and Co-Founder, President and Chief Science Officer of Synthonics, Inc. said, “Our conclusions are that RSBT-001 approached normalization of IL6, IFNγ, IL-12p70 and IL-1β relative to baseline at the 12 and 24 hours timepoints. Moreover, RSBT-001’s response was similar to dexamethasone’s 2.5 mg/kg responses. In this trial, RSBT-001 demonstrated exactly what we want to accomplish with any anti-inflammatory agent: down regulate cytokines to the appropriate therapeutic level but not eliminate cytokines altogether. Completely eliminating cytokine expression is what corticosteroids, like dexamethasone, can do, which allows secondary infections to occur.”

 

Adding to the discussion, Hongwei Yu, Ph.D., a professor in the Marshall University School of Medicine and one of the lead researchers on the study noted, “The results of the proof-of-concept study for RSBT-001 were exciting. We are looking forward to participating in additional studies to determine the precise dosing of RSBT-001 that is most effective at preventing lung inflammation as well as its safety and adverse event profile.”

 

RS BioTherapeutics has initiated a second study with Marshall to further evaluate the impact of RSBT-001 on pulmonary inflammation.

 

About RS BioTherapeutics
Founded by experts in pulmonary diseases and the endocannabinoid system, RS BioTherapeutics is a wholly owned subsidiary of Real Science Holdco LLC. The company’s mission is to harness its strong and thorough understanding of the Endocannabinoid System in the research, development, and commercialization of forward-thinking interventions to address chronic and acute pulmonary inflammation-based diseases. More information on RS Biotherapeutics can be found at www.rsbiotherapeutics.com.

 

About Synthonics
Synthonics, Inc. is a privately-held specialty pharmaceutical company focused on the discovery and development of patentable drugs that incorporate its proprietary metal coordination chemistry. It binds metals to known pharmaceutical agents to create new products that are better absorbed and thus have greater therapeutic benefits than their predecessors. More information on Synthonics can be found at www.synthonicsinc.com.

 

Media Contact:
David Gutierrez, Dresner Corporate Services, (312) 780-7204, dgutierrez@dresnerco.com

View original publication | Global News Wire

RS BioTherapeutics Enters Into License Agreement With Synthonics for First Investigational Compound

Aims to harness the power of the Endocannabinoid System to create life-changing medicines

May 23, 2022 11:00 ET | Source: RS BioTherapeutics

 

CUMBERLAND, Md., May 23, 2022 (GLOBE NEWSWIRE) — RS BioTherapeutics, whose mission is to harness its strong and thorough understanding of the endocannabinoid system to research, develop and commercialize interventions to address chronic and acute pulmonary (lung) inflammation-based diseases, is pleased to announce that is has entered into a license agreement with Synthonics, Inc. for the exclusive, worldwide right to use Synthonics’ metal coordinated cannabinoid in nebulized form for the treatment of pulmonary inflammatory disorders. RS BioTherapeutics is developing its lead compound, RSBT-001, as both an alternative and a complement to corticosteroids for the treatment of chronic obstructive pulmonary disease (COPD).

 

COPD is a chronic inflammatory lung disease that causes obstructed airflow from the lungs and includes emphysema, chronic bronchitis, asthma and more. According to the American Lung Association, 156,045 people died from COPD in 2018, making it the third highest disease-related cause of death behind heart disease and cancer. It is estimated that more than 250 million people globally may have the condition and more than 65 million people around the world have moderate or severe COPD. Experts predict that this number will continue to rise worldwide over the next 50 years. The CDC estimates that 16 million Americans suffer from COPD. People with COPD are at increased risk of developing heart disease, lung cancer, and a variety of other conditions. If chronic pulmonary inflammation is untreated, it can lead to fibrosis, organ damage, and loss of organ function.

 

Commenting on the potential benefits of this first investigational compound, RSBT-001, Justin Molignoni, CRNP, Chief Strategy Officer and Co-Founder of RS BioTherapeutics, said, “Alternatives to corticosteroids are needed for people with chronic inflammatory diseases. We believe RSBT-001 has the clinical potential to address exacerbation and prevent progression of both acute and chronic pulmonary inflammation related to respiratory diseases including COPD, SARS-COV-2, Cystic Fibrosis, Asthma, Bronchitis, and Acute Respiratory Distress Syndrome.”

 

John Tinkham, CEO and Co-Founder of Synthonics, added, “We believe that metal coordination can significantly enhance the effectiveness of cannabinoid-based pharmaceuticals and are delighted to partner with RS BioTherapeutics on this project. We look forward to working closely with RS BioTherapeutics to assist on the development of RSBT-001.”

 

Various sources estimate the global pulmonary drug delivery systems market was approximately $51 billion in 2021, and it is expected to be worth around $92 billion by 2030, with a compound annual growth rate of 6.6 percent within in next 10 years.

 

About RS BioTherapeutics
Founded by experts in pulmonary diseases and the endocannabinoid system, RS BioTherapeutics is a wholly owned subsidiary of Real Science Holdco LLC. The company’s mission is to harness its strong and thorough understanding of the Endocannabinoid System in the research, development, and commercialization of forward-thinking interventions to address chronic and acute pulmonary inflammation-based diseases. More information on RS Biotherapeutics can be found at www.rsbiotherapeutics.com.

 

About Synthonics
Synthonics, Inc. is a privately-held specialty pharmaceutical company focused on the discovery and development of patentable drugs that incorporate its proprietary metal coordination chemistry. It binds metals to known pharmaceutical agents to create new products that are better absorbed and thus have greater therapeutic benefits than their predecessors. More information on Synthonics can be found at www.synthonicsinc.com.

 

Media Contact:
David Gutierrez, Dresner Corporate Services, (312) 780-7204, dgutierrez@dresnerco.com

 

View original publication | Global News Wire